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Cortistatin offers mechanistic clarity -- a well-defined receptor pharmacology, a specific mechanism of cortical synchronization, and validated homeostatic sleep factor properties -- but is limited to preclinical research with no human data and an impractical administration route

Based on these data, the authors suggest that injection of ADSVCs is safe and efficient for AA treatment

Meta-analysis was performed using a random-effects approach in case of significant between-study heterogeneity

strength (46% vs

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