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J Ethnopharmacol 182:5056 Singh Grewal A et al (2016) Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases

Effector phase Whenever the same allergen is encountered again during the effector phase, IgE bound to FcRI on the surface of mast cells and basophils cross-links, activating and degranulating them and releasing reactive mediators that cause an acute systemic allergic response (Pasha et al