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High levels of UA inhibit the growth of the pancreatic -cell lines (INS-1 and RIN-m5F) in a time- and dose-dependent manner via the ROS-AMPK-ERK signaling pathway [31]

The resultant Slc25a39 fl/fl mice were mated with erythroid-lineage specific Cre-recombinase ( ErGFP- cre) mice to generate an erythroid-specific conditional knockout mice

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