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Both the low expression of Keap1 and the overexpression of Nrf2 led to a significant increase in xCT mRNA levels (up to a 5-fold increase), which subsequently reduced ROS formation

Oliveira KRHM, dos Anjos LM, Arajo APS, Luz WL, Kauffmann N, Braga DV, da Conceio Fonseca Passos A, de Moraes SAS, de Jesus Oliveira Batista E, Herculano AM (2019) Ascorbic acid prevents chloroquine-induced toxicity in inner glial cells

The livers detoxification process is complex, but most simply is divided into two steps, aptly named Phase 1 and Phase 2

77 Overexpression of HSP60 in animal models alleviates fat accumulation and improves mitochondrial function, underscoring its therapeutic potential

Ethics approval All animal studies were approved by the Institutional Animal Care and Use Committee of Augusta University (Animal Use Protocol #20170868) and were conducted in accordance with the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals