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This paradoxical nature extends to OS, which increases PRKAA1/AMPK1 to induce glycolysis

Given that the kidney is the primary site of clearance for small peptides, moderate-to-severe renal impairment may reduce clearance and increase sermorelin exposure

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Our previous study (Krupodorova et al

3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019