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In addition, the proposed structureactivity relationships are based on a limited set of compounds, making it difficult to establish definitive correlations regarding the influence of arene ligands, curcuminoid backbones, or PTA coordination on biological behaviour

Diabetic Retinopathy: Mitochondrial Dysfunction and Retinal Capillary Cell Death

Other studies have shown that ROS production in response to glutamine deprivation increases the expression of p53-dependent genes ( Gadd45a, Cdkn1, and Sestrin2 ) via B55 or IKK 124,125