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leucine-rich repeat kinase 2 (LRRK2) [185, 186], autophagy genes ATG16L1/IRGM/NOD2 [187], G protein-coupled receptor 35 (GPR35)-extracellular signal-regulated kinase (ERK) [188] and CR6 interacting factor 1 (CRIF1)-mitochondria-TH17 [189] are associated with the neuro-immune, autophagy, inflammation, and metabolism axes, respectively

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