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The two visited Ecuador, where they worked with Western doctors alongside shamans and indigenous healers to study integrative medical systems

Biguanides do not act as true hypoglycemic agents (82, 83)

Dosages in the trials included in the meta-analyses ranged from 100 to 300 mg per day for 412 weeks in most studies, with two studies lasting 24 and 48 weeks, respectively

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Dual-responsive, methotrexate-loaded, ascorbic acid-derived micelles exert anti-tumor and anti-metastatic effects by inhibiting NF-B signaling in an orthotopic mouse model of human choriocarcinoma