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DZN induces the generation of ROS and cell death in testis Excessive production of reactive oxygen species (ROS) can modify and damage cellular proteins, lipids, and DNA, ultimately leading to cell death

SN: serial number, RCT: randomized controlled trial, 8-OHdG: 8-hydroxy-2 -deoxyguanosine, IMI: iopathic male infertility, UMI: unexplained male infertility, RPL: recurrent pregnancy loss, ROS: reactive oxygen species, N/A: not available, MDA: malondialdehyde, TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labelling, SDF: sperm DNA fragmentation, ICSI: intracytoplasmic sperm injection, DFI: DNA fragmentation index, OS: oxidative stress, SOD: superoxide dismutase, GSH: gluthatione, TAC: total antioxidant capacity, SCSA: sperm chromatin structure assay, CoQ: coenzyme Q, FSH: follicle-stimulating hormone, LH: luteinizing hormone, IVF: in vitro fertilization, -HCG: beta-uman chorionic gonadotropin, OAT: oliasthenoteratozoospermia, PRL: prolactin, TSH: thyroid-stimulating hormone, ART: assisted reproductive techniques, TBARS: thiobarbituric acid reactive substances, GPx: glutathione peroxidase, PRM: protamine, CMA3: chromomycin A3

While some studies suggest that HRT initiated early in menopause may provide neuroprotective benefits, others show inconsistent results [108]

doi: 10.1007/s10067-017-3859-3 122 WjcikPGgotekAarkoviNSkrzydlewskaE

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