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The inhibition by cyanide of the activity of metalloenzymes, including those containing Fe, Zn or Cu, has been strongly and widely demonstrated (Fig

Within cells, CYPs are predominately membrane-bound on the ER or mitochondria, with the ability to move along the membrane surface as the catalytic domain remains on the cytosolic side but is anchored by the N-terminal transmembrane on the luminal side (rejber et al., 2018)