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However, the so-called heme-anemic proteins with an incomplete heme saturation naturally occur outside the circulatory system [ 150 ]

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To date, a small handful of iron chelators have been approved by the FDA or have undergone clinical trials to treat iron overload-related diseases, transplantation, organ injury, and HCC

Misdiagnosing B12 deficiency as thrombotic microangiopathy (TMA) or other serious blood disorders can result in unnecessary procedures like plasma exchange, immunosuppressive therapy, or bone marrow biopsies, which can delay the right treatment [12]

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