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Comparing relative changes of the two groups, we observed more beneficial effects of the non-reducing LEDD group regarding the total scores of depressions and anxiety, domains of depression including anxiety/somatization, weight loss, cognitive disturbances, retardation symptoms, sleep disturbances, and hopelessness symptoms (Table 3)

However, the conversion of the recruited monocytes from the pro-inflammatory (M1) to the pro-regenerative (M2) phenotype is critical for regeneration