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In individuals with pre-existing gastrointestinal conditions such as inflammatory bowel disease, coeliac disease, or irritable bowel syndrome, introducing any new supplement may temporarily affect bowel habits as the digestive system adapts

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Inhibiting the activity of CD38 may reduce the severity of cardiac remodeling and heart failure symptoms by diminishing myocardial hypertrophy and fibrosis, resulting in the development of CD38 inhibitors for preclinical and clinical studies