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Following eligibility assessment based on predefined inclusion criteria, that is, relevance to cellular senescence mechanisms, therapeutic targeting (senolytics or senomorphics), and availability of clear mechanistic or clinical outcome data, 261 peer-reviewed articles were finally included in this review

They were then washed with 0.15 M HEPES three times for 5 min, postfixed with 1% OsO4 (EMS, Hatfield, USA) in 0.1 M Na-cacodylate-buffer (Merck, Darmstadt, Germany) at 4 C for 1 h

Given its multifaceted tissue-protective activities, ARA 290 represents a promising candidate for advanced wound care strategies, with future studies warranted to explore localized delivery systems that maximize its therapeutic potential while minimizing systemic exposure

It is not a recommended route

Damas P