It's another possible mechanism for affecting metabolism
Front Cardiovasc Med 10:1005408 Yang CC, Chen KH, Yue Y, Cheng BC, Hsu TW, Chiang JY et al (2024) SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal protection
Injection site reactions (irritation, erythema, induration, pain, itching) in approximately 70% of subjects on drug and rarely on placebo more severe and/or prolonged after higher doses
The compound of 1 is (a) phenyl substituted with one to three substituents independently selected from hydroxy, halogen, hydroxy, CN, C 1-3 alkyl, C 1-3 alkyl-CN, OC 1-3 alkyl-CN, C 1-3 haloalkyl, C 3-6 cycloalkyl, OC 1-3 alkyl, OC 1-3 haloalkyl, OC 3-6 cycloalkyl, 5 membered heteroaryl containing 2 nitrogen atoms, S(O) 2 C 1-6 alkyl, S(O) 2 NHC 1-3 alkyl, or C 1-3 alkylNH 2 , and optionally further substituted with 1 or 2 substituents independently selected from halogen, C 1-3 alkyl, C 1-3 haloalkyl, CN, or OH
OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination