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However, these models fail to accurately replicate physiological conditions due to their simplified (2D) microenvironment, phenotypic and genetic instability and functional alterations in culture [48]

(PubMed) Reyes LH, Encinar JR, Marchante-Gayon JM, Alonso JI, Sanz-Medel A

While selenium holds promise in prostate cancer management, the heterogeneity of the disease and the complexity of seleniums interactions with various patient characteristics underscore the need for personalized approaches and further research

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