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10.1111/acel.12368 Aging cell 10 BianchiS.MacchiarelliG.MicaraG.LinariA.BoninsegnaC.AragonaC.et al (2015)

Its a clever idea, but its far from perfect

coignetiae 23 treatment showed a beneficial effect on NAFLD by reducing the percentage of fibrosis area and NF-B expression

snap was kept at 80 C in liquid nitrogen

Agents that shift Hb oxygen affinity present some concerns of potential negative effects as the bound oxygen cannot be off loaded in tissues with high oxygen requirements, particularly concerning in a disease characterized by decreased oxygen delivery (Thompson, 2019)