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The physiological effects of GABA depend not only on its concentration but also on factors such as receptor density and subunit composition, chloride ion gradients, and presynaptic release efficacy

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compositions and/or formulations of the invention treats, alleviates, or ameliorates conditions, disorders and diseases of skin and mucosa in humans associated with changes in extracellular matrix components which are not related to aging and which are selected from the group of wounded skin, damaged skin after cosmetic and dermatological procedures, atrophy of skin and mucosa due to other causes than aging (e.g., emotional stress, use of oral contraceptive pills, use of aromatase inhibitors, due to surgery, etc.), and for other conditions, and/or disorders and diseases of skin and mucosa in humans associated with changes in extracellular matrix components which are not related to aging

Over time, many studies have been demonstrated the importance of glutamine concentration in cell migration and the expression of adhesion molecules