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Observational studies in athletic populations have reported persistent systolic hypertension, concentric left ventricular hypertrophy, and impaired diastolic function during and following anabolic steroid exposure ( Endothelial dysfunction is considered a key link between AAS abuse and macrovascular disease

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showed that Hp KO mice experienced greater oxidative damage and renal tubular injury compared to wild-type mice when challenged with hemolysis-inducing agents ( In addition to the scarcity of human studies testing Hx replenishment as a therapeutic in SCD, another foreseeable limitation of this strategy is the cost

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