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The pivotal early-efficacy readout in obesity came from a randomized, double-blind, placebo-controlled, dose-finding Phase 2 trial published in The Lancet Diabetes & Endocrinology (le Roux and colleagues), conducted across 43 centers in 12 countries and registered as NCT04667377

Larger sample sizes increase statistical power to detect real effects

Growth hormone physiology and aging

Limitations The present study has several limitations

Hu E, Wang D, Chen J, Tao X (2015) Novel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells