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Similarly, a 2017 double-blind, placebo-controlled trial found that oral administration of ALA (1,200 mg/day) for eight weeks induced mild weight loss accompanied by a reduction in waist circumference

Amino acid metabolism, among the three interconnecting central metabolic axes (carbohydrate, amino acid and lipid), also plays a crucial role in therapeutic intervention [25]

Future studies should target adequate consideration of sex differences in clinical investigation of MASLD to fill current gaps and implement precision medicine for PWH