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Therefore, in line with 3 R animal experimental principles, we chose to conduct our proof-of-concept study directly in elephants since an in-target-species trial in a real-world setting provides an accurate reflection of the vaccines safety and immunogenicity, avoiding reliance on models that poorly recapitulate elephant immunology

Epithelial-specific S100A2 transgenic mice exhibit increased proliferation and delayed skin wound repair (57)

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