Sep 24,2024 Bestchrom About GST Glutathione S-transferase (GST) belongs to the polygenetic, multifunctional phase II metabolic enzyme family, it is a macromolecular protein with relative molecular weight of 26kDa
Genes were scored in batches of up to 10 using the following prompt: For the following genes: [list symbols of up to 10 genes] 1
Nature 583 , 834838 (2020)
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Blocking this antioxidant axis with SLC7A11 and GPX4 inhibitors (ferroptosis inducers) such as the small-molecule Erastin and RSL3, respectively, leads to uncontrolled accumulation of lipid peroxides at the plasma membrane and other endomembranes within the cell, which promotes membrane permeabilization, damages membrane integrity and ultimately induces ferroptosis [34, 38]
