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Coppers impact on NFKB regulation is complex and context-dependent, showing both inhibitory and activating effects

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Saghazadeh A, Rezaei N (2017) Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury

The majority of intracellular proteins are degraded by the ubiquitinproteasome system (UPS), a multi-enzyme process that involves the covalent conjugation of ubiquitin to a substrate protein and its recognition and degradation by the core multicomponent proteolytic complex of the UPS, the proteasome