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SKU: 73833179131
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Competing interest COPE No competing interests were disclosed

Evidence and Clinical Research Evidence-Level Definitions: Established clinical evidence: Supported by multiple peer-reviewed human studies

62,99,100 Together, these reports provide strong evidence that after an APAP overdose, in vivo and in isolated hepatocytes in culture, ferrous iron can be released from lysosomes and then taken up into mitochondria via the MCFU, where it contributes to MPTP opening and cell death (Fig