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Thus, all PROSPERO guidelines were incorporated during the execution of the literature review ( 3 Multifaceted effects of metformin: understanding its pleiotropic properties Metformin provides hypoglycemic effect through various mechanisms, such as inhibition of gluconeogenesis in the liver, increased glucose uptake in skeletal muscle and hepatocytes, decreased glucose absorption in the gastrointestinal tract ( Apart from its hypoglycemic effects, metformin has been shown to have several other beneficial effects on lipid profile, immune and coagulation responses, and hormone synthesis ( Metformin also has a significant impact on the PCOS, decreasing luteinizing hormone and androgen synthesis, resulting in normalizing the menstruation cycle ( The pleiotropic effects of metformin are achieved through its ability to modulate multiple factors at the molecular level

Firstly, the review seeks to evaluate the clinical evidence supporting the effectiveness of silymarin in improving liver function and managing symptoms in various CLDs, including NAFLD, chronic hepatitis, alcoholic liver disease (ALD), and cirrhosis

Because glutathione is vital for nearly all cells, the symptoms of glutathione deficiency are widespread, including: Chronic fatigue or brain fog Recurrent illnesses or slow illness recovery Poor detoxification (signs include intolerance to smells, jewelry, or personal care products

10.1002/chem.201502474 251 SessoH

2023;39(1-3):141-161.[DOI] 33