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The top 5 enriched pathways of the PLS2 + genes were Translation, Metabolism of RNA, plasma membrane bounded cell projection assembly, Neddylation, and SUMO is transferred from E1 to E2 (UBE2I, UBC9)

It is characterized by rapid neuronal death and extracellular matrix degradation post-injury, culminating in cavity formation and long-term neurological deficits (217, 218)

Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by l-arginine and tetrahydrobiopterin

Tau protein hypothesis Besides the A protein deposition, hyperphosphorylated or abnormally phosphorylated Tau protein aggregated into neuronal neurofibrillary tangles is also one of the primary pathogeneses of AD [35,36,37]