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Abbreviations 4E-BP1 Eukaryotic translation initiation factor 4E-binding protein-1 6W Six-minute walk test AEs Adverse events BMI Body mass index Comp Composite endpoint DXA Dual-energy X-ray absorptiometry ITT Intent-to-treat LS Lower strength MM Muscle mass mTOR Mammalian target of rapamycin MuRF1 Muscle RING-finger protein-1 NNHPD Natural and non-prescription health products directorate NSAID Non-steroidal anti-inflammatory drug PP Per-protocol QoL Quality of life S6K p70-S6 kinase UPS Ubiquitinproteasome system US Upper strength Additional file Contributor Information Malkanthi Evans, Email: [email protected]

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The in silico experiment revealed a well-defined substrate binding pocked that did not cause steric conflicts when the 3-hydroxy group of MSA was added and the model was energy minimized

Complete blood count (CBC) and CD34+cell enumeration was done on donor's peripheral blood samples during the mobilization period and immediately prior to leukapheresis (between day 4 to day 6 of mobilization)

Hajjar DP, Haberland ME