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Another study confirmed this finding, showing that during hindlimb unloading and reloading, lipid peroxidation in skeletal muscles significantly increases, accompanied by dysregulation of heat shock proteins (HSPs), especially a decrease in Hsp70 and Hsp25 expression, which further aggravates muscle damage and atrophy (67)

Hansen AR, et al

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While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

BMC Cancer 2013;13:307