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1 H NMR (400 MHz, D 2 O, ppm): = 4.674.57 (m, 1H), 3.98 (s, 2H), 3.90 (t, J = 6.4 Hz, 1H), 3.813.72 (m, 1H), 3.273.14 (m, 1H), 3.102.91 (m, 2H), 2.852.74 (m, 1H), 2.602.45 (m, 2H), 2.252.11 (m, 2H)

These results were also confirmed by direct blood-feeding experiments

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In a state of elevated DA or increased DA oxidation exemplified by chronic or repeated administration of APDs, higher level of DA is toxic to mitochondria of neural cells in the brain (202)