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A deficiency in either vitamin can impair homocysteine remethylation, highlighting the interdependence between folate and B12 for optimal metabolic function

Additionally, for various pathological conditions, including neurodegeneration, lysosomal and autophagy dysfunction occur concomitantly and both contribute to the disease progression [38,39], further supporting the close connection between lysosomal dysfunction and autophagy inhibition

The following studies were all carried out in healthy subjects

Whole body-ethyl acetate (WBEA), whole body-butanol (WBBU), and body wall-ethyl acetate are extracts of the sea cucumber Holothuria scabra (BWEA)

IDH1 is a cytosolic enzyme that metabolizes isocitrate to -KG to generate cytosolic NADPH