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Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers

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Pharmaceutical inhibitors like finasteride block both types systemically, which explains their effectiveness but also their side effect profile

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399 Nanodiscsnoncovalent nanoscale assemblies composed of a lipid bilayer surrounded by amphiphilic scaffold proteins 400 have also been used to synthesize diverse membrane proteins including oligosaccharyltransferases (OSTs), 270,401 the methyltransferase Opi3, 402 the antigenic vaccine carrier pore protein PorA, 141 and the chemokine GPCR CCR5