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Despite the promising results in preclinical and clinical studies, as noted by To advance the therapeutic potential of -elemene, future research must address these design flaws by implementing more rigorous, randomized controlled trials with standardized dosing regimens, comprehensive pharmacokinetic evaluations, and long-term safety and efficacy assessments

Early granulomas with high bacterial loads are influenced by mast cells, type 2 immunity, and tissue remodeling

Kippler and Oskarsson, 2024) (Figure 1B)

Integrating genetic data with robust clinical variables and machine learning approaches can improve prediction, with some models explaining up to 13.7% of the variance in lithium response, but these require further validation [4, 23, 82]

Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt/-catenin signaling pathway