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CH retic and percentage of reticulocytes with low hemoglobin [% CH retic ]) can be helpful in identifying iron restricted erythropoiesis before changes in the traditional RBC indices of MCV and MCHC or even the development of anemia

Taken together, microbial dysbiosis, activation of RAS, oxidative stress, and inflammation form a complex, interdependent pathophysiological network that drives the onset and progression of DKD