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Glutamate is an excitatory neurotransmitter, and its presence can lead to excessive calcium influx triggering oxidative stress, mitochondrial dysfunction, and caspase activation, ultimately resulting in neuronal cell death

[DOI] [PubMed] [Google Scholar] Lewis DA, Levitt P

For this study, a nested casecontrol design was employed in which patients were selected based on their overweight/obesity status and control subjects were age- and sex-matched subjects, both recruited at a ratio of 1:1.6

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