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The dose then increases in 2.5 mg increments to achieve the desired weight loss, up to a maximum dose of 15 mg

Which explains why the signs of aging show up differently for everyone

As more and more high dose oral B12 is administered the situation gradually gets worse and worse, because now much of the HC secreted in saliva (Collins etal 1999) already has inactive B12 bound to it, and so this HC-B12 complex can no longer protect incoming B12 from acid hydrolysis

This clinical observation is possibly because the methylcobalamin delivered by this method is better absorbed into the bloodstream, or it is more bio-available, or the effect is more noticeable because of the constantly higher blood level

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