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Knockout of ATG5 or ATG7 can shorten the lifespan of experimental animals, whereas overexpression of ATG5 can prolong the lifespan

Kriegstein and Alvarez-Buylla, 2009

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In this case, during morphine treatment, morphine/MOR complexes would accumulate at the plasma membrane and recruit signaling pathways involved in tolerance such as ACase superactivation and NMDA receptor regulation (Finn and Whistler, 2004)