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PGA is a degradation product of glutathione metabolism within the -glutamyl cycle and is directly associated with disruptions in GSH homeostasis and GSH depletion [44, 45, 65, 66]

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Similarly, Warburg observed that resting leukocytes performed aerobic oxidative metabolism but shifted toward aerobic glycolysis upon stimulation

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Doses often cited range from 200 to 500 mcg (micrograms) administered daily, although some go up to 1000 mcg

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