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Supporting this notion, we showed that in rat cerebral cortical cultures, short term (48 h) proteasome inhibition results in the accumulation of soluble Ub-proteins without significant loss in neuronal viability (Metcalfe et al., 2012)

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Although the PPP operates in all cells, with high levels of expression in the above indicated tissues, the highest levels of PPP enzymes (in particular glucose 6-phosphate dehydrogenase) are found in neutrophils and macrophages