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However, TGF- knockout mice display increased NO production and iNOS expression, suggesting its regulatory function in dampening pro-inflammatory responses, including iNOS expression ( Figure 9 )

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PubMed Europe PMC Scholia Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)

Pharmacological Reports , 2018 Anti-Inflammatory Effects It reduces levels of pro-inflammatory cytokines like TNF- and IL-6 while modulating nitric oxide (NO) pathways that contribute to gut permeability and motility issues