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Shklar and coworkers (173) examined the effects of methotrexate on hamster buccal pouch carcinomas generated by 9,10-dimethyl-l,2-benzanthracene and found that the methotrexate-treated group reported tumors that were larger and more anaplastic and that they progressed more quickly than the control group

An alternative starting protocol uses 1mg for the first four weeks before moving to 2mg, then following the standard escalation from there

2021;35: e22830

Despite these promising preclinical advances, neither PAMAM dendrimers nor PLGA-based formulations delivering nucleic acids for liver malignancies have progressed to clinical trials, underscoring the persistent challenges of translating polymeric nanoparticle systems from bench to bedside

Arzneimittelforschung 62 (5), 222229