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Organic anion-transporting polypeptide (OATP) family function independently from ATP and sodium gradient [118], and is found on the basolateral membrane of the hepatocytes and on the apical membrane of intestine epithelial cells [119], using the following transport substrates: bile salts, organic anions, steroids, leukotrienes, and prostaglandins [120]

Typically, MT is found in the cytoplasm, but it can also translocate into the nucleus to safeguard DNA from damage and interact with transcription factors, which will be further elaborated on later

All data represent the mean SEM, n=6

Maternal factors like age, parity, history of preeclampsia, interpregnancy intervals, obesity, ethnicity, and medical conditions increase the risk of preeclampsia

Tirzepatide works through the incretin system to reduce appetite and improve metabolic signaling