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Abbreviations ALA: Alpha-lipoic acid (-lipoic acid) APO: Apocynin CAT: Catalase GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Reduced glutathione GSHt: Total glutathione GSSG: Glutathione disulfide HFD: High-fat diet LFD: Low-fat diet OS: Oxidative stress OVA: Ovalbumin P: Probiotic ROS: Reactive oxygen species SFD: Standard fat diet SOD: Superoxide dismutase References Maniscalco M, Paris D, Melck DJ, DAmato M, Zedda A, Sofia M, Stellato C, Motta AJ

This qualitative assessment, detailed in Supplementary File 2, reinforced GPX4s position as the top candidate from module M14.51, providing a strong rationale for its selection for further investigation and potential inclusion in a targeted blood transcriptional assay

Improved Body Composition Elevated GH is intrinsically linked to enhanced lipolysis (fat breakdown) and creating a favorable metabolic environment for building lean muscle mass