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Human skin, for example, has proteases that could chew up peptide bonds if they entered the solution

Ordinarily, the body manages this on its own

Current investigations continue to assess how peptide-based compounds interact within multi-pathway signaling environments, including potential influences on circadian regulation, antioxidant-associated processes, and system-level biological responses in controlled laboratory models

This assumption is reinforced by the observation that N-acetyl-L-cysteine (NAC, an antioxidant thiol and a precursor for L-cysteine, the rate-limiting amino acid in the biosynthesis of glutathione [14, 17, 112]) imposes a reducing environment, thereby protracting HIF-1 stability in the cytosol and subsequently favoring its translocation and activation [13, 14, 53, 54, 82, 111]

Psychoneuroendocrinology 64 , 150163 (2016)