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(2014) 9:e107626

Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

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These results indicate that VNS can effectively improve the mitochondrial morphological changes and mitigate mitochondrial damage in cardiomyocytes induced by hepatic ischemiareperfusion injury, while erastin can counteract this protective effect