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Pharmacological agents targeting 7nAChR have shown remarkably promising efficacy and safety profiles in many preclinical and clinical studies

The RAPID and RAPID Open Label Extension (RAPID-OLE) studies represent the largest multicenter randomized placebo-controlled trials conducted on this therapy

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A notable example is vitamin C (ascorbic acid) and its stable derivative, L-ascorbic acid 2-phosphate, which significantly enhance the proliferative capacity and effector functions of T cells, a unique subset of T lymphocytes that bridge innate and adaptive immunity

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