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The plasma catecholamine concentrations were evaluated by one-way ANOVA, first including all groups within each strain, then including groups within each of the four protocols, or including the controls, AdrX + PBS-, hexamethonium-, losartan-, and NX-pre-treated groups

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Biological Activities of Curcuminoids, Other Biomolecules from Turmeric and Their DerivativesA Review

156 Apoptosis Excessive intracellular ROS activate proapoptotic BH3-only proteins (e.g., BAD, BIM, PUMA, NOXA), which displace antiapoptotic BCL-2 family members (e.g., BCL-2, BCL-XL), enabling BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP)