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Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells

Vogt, A., Mandt, N., Lademann, J., Schaefer, H

doi: 10.1016/j.jconrel.2020.06.019

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Studies in obese rodents fed high-fat diets for extended periods show that diminished carnitine reserves in skeletal muscle are accompanied by marked perturbations in mitochondrial fuel metabolism, including reduced complete fatty acid oxidation, elevated incomplete -oxidation, and impaired substrate switching from fatty acid to pyruvate oxidation