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For instance, uteroplacental embolization between 109 and 130 days, but not between 120 and 140 days, increased surfactant protein levels in near-term lambs (286, 287), although both IUGR models showed fetal pulmonary structural immaturity despite elevated fetal cortisol levels

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Extremely high levels of CN- (millimolar) stopped transcriptional activation, but if additional Cu1+ was added, activation ensued, suggesting that copper binding to the protein was reversible