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For a comprehensive review, see reference (98)

Low methionine levels can affect the production of A-adenosylmethionine (SAMe), a major methyl donor for the central nervous system and an essential nutrient required for the production of neurotransmitters

Suspected adverse reactions to any unlicensed compound should be reported to the MHRA via the Yellow Card Scheme at yellowcard.mhra.gov.uk

There can be tolerance with repeated use, which degrades efficacy and increases doses, leading to safety concerns

Wu, A highly active copper-nanoparticle-based nitrate reduction electrocatalyst prepared by in situ electrodeposition and annealing